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Common side effects of simvastatin

Zhonglin, H. Toxicity study for Monascus purpureus red yeast extract. If you also take cholestyramine, colesevelam, colestipol: these other medicines should be taken at least 1 hour after or 4 hours before you take TriCor. Zetia lowers bad LDL cholesterol by blocking cholesterol absorption in your small intestine. Patients taking digoxin should be monitored appropriately when VYTORIN is initiated. Take colchicine by mouth with or without food. cost of bimatoprost in england

There may be new information

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.

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Based on 10 mg-dose of ezetimibe. Lin, C. C. Red Yeast Rice for a patient with olanzapine-induced dyslipidemia: a test-and-retest case report. Prog. What are the ingredients in VYTORIN?

Simvastatin dosage

Retrieved 1 December 2012. Journal of Nutrition, 2001; vol 131: pp 2275-2279. HDL actually works to clear cholesterol from the blood. Ma L, Gao Y Li BZ. Observations of the therapeutic effects of Zhibituo for treatment of 50 patients with hyperlipidemia.

MVE and MAE in this CKD population

Aprepitant: May increase the serum concentration of CYP3A4 Substrates. Severe renal dysfunction: Initial dose should be 5 mg orally once a day in the evening and should be closely monitored. Hosenpud, J. Myolysis and acute renal failure in a heart-transplant recipient receiving lovastatin. Do not keep outdated medicine or medicine no longer needed. The usual maximum dose for the simvastatin in this medication is 40 milligrams a day. If you have been instructed by your doctor to take more than 40 milligrams of simvastatin, continue on that same dose. However, promptly talk with him or her about the risks and benefits of your higher dose. Some medications might decrease how quickly the liver breaks down red yeast. Taking red yeast along with some medications that decrease the breakdown of other medications in the liver can increase the effects and side effects of red yeast. Before taking red yeast, talk to your healthcare provider if you are taking any medications that are changed by the liver. IV, and V dyslipidemias. Zhang QL. Comparative interventional therapies of dyslipidemia by simvastatin and Zhibituo with 60 cases.

Keep out of the reach of children

It was the statin with olefactory hallucinations. I also thought that my battery was boiling and that I was smelling the sulfuric acid. My doctor thinks that I'm making this up and he gets mad. Because of the increased risk of myopathy including rhabdomyolysis associated with the 80 mg dose, patients unable to achieve their LDL-C goal utilizing the 40 mg dose should not be titrated to the 80 mg dose, but should be placed on alternative LDL-C-lowering treatments that provide greater LDL-C lowering. Store simvastatin at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep simvastatin out of the reach of children and away from pets. Gu ZY, Lu ZF Zhu HQ. Observations on the therapeutic effects of Zhibituo for treatment of 158 patients with hyperlipidemia. Some medicines, like and progestins, may increase "bad" cholesterol and decrease the "good" cholesterol. Michael Miller, MD, director of the Center for Preventive Cardiology at the University of Maryland Medical Center. "Lifestyle changes certainly are the cornerstone of cholesterol reduction. Some drugs, such as and progestins, can increase the "bad" cholesterol and decrease the "good" cholesterol. Treating high cholesterol along with a cholesterol-lowering diet. It may also be used for other conditions as determined by your doctor. Tell your doctor if you have ever had any unusual or allergic reaction to simvastatin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. cytoxan

Simvastatin adult dosage

Experts say another problem is that people may suspect statins when other conditions are really causing their symptoms. Sobh, M. Efficacy and safety of Monascus purpureus Went rice in children and young adults with secondary hyperlipidemia: a preliminary report. Yang WJ, Fu XJ. Comparison of the therapeutic effects of Zhibituo and simvastatin for treatment of hyperlipidemia. Using simvastatin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. LDL levels tend to rise. Zhao YL, Ouyang HB. Observation on therapeutic effects of Zhibituo for treatment of hyperlipidemia. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. The dosage is based on your medical condition, response to treatment, age, and other you may be taking. High cholesterol does not have any symptoms. So you can be completely unaware that your are getting too high. Constipation; headache; mild stomach pain; nausea. Lai, M. M. Efficacy of Monascus purpureus Went rice on lowering lipid ratios in hypercholesterolemic patients. Pan, T. M. Proteomic analysis of Caco-2 cells treated with monacolin K. J Agric. Cheng, J. T. Plasma glucose-lowering action of Hon-Chi in streptozotocin-induced diabetic rats. Horm. propranolol

What conditions does simvastatin treat

Single-strength: one can of frozen concentrate diluted with 3 cans of water. CHILDREN younger than 10 years old; safety and effectiveness in these children have not been confirmed. Your is supposed to carry oxygen to all parts of your body, including your muscle. Wang DG, Li D Nie ZY. Cost-effectiveness analysis on Xuezhikang and pravastatin treatment of hypercholesterolemia. Though less rhythmic than other types of massage, deep tissue massage can be quite therapeutic -- relieving chronic patterns of tension and helping with muscle injuries, such as back sprain. It works by blocking an enzyme that is necessary for your body to make cholesterol. Lowering cholesterol levels in the blood reduces the chance of heart disease, heart attacks, and strokes. Simvastatin is effective alone or in combination with bile acid sequestrants. Dosing should occur either more than 2 hours before or more than 4 hours after administration of bile acid sequestrants. Do not take 2 doses at once. Chinese patients; some non-US labeling state this combination is not recommended in any Asian patients. Caution should be used when treating Chinese patients with simvastatin doses exceeding 20 mg per day coadministered with lipid-modifying doses of niacin-containing products. The risk for myopathy is dose-related; therefore, Chinese patients should not receive simvastatin 80 mg coadministered with lipid-modifying doses of niacin-containing products. What Are Possible Side Effects of Lipitor? There are several different types of prescription drugs that lower LDL. Get to know what each of them does. There are two forms of cholesterol that many people are familiar with: Low-density lipoprotein or "bad" cholesterol and high-density lipoprotein HDL or "good" cholesterol. Muscle pain, tenderness and weakness myopathy. cheap baclofen pct

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Severe allergic reactions rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness; breathing problems eg, persistent cough, shortness of breath; burning, numbness, or tingling; change in the amount of urine produced; confusion; decreased sexual ability; depression; difficult or painful urination; dizziness; fever, chills, or persistent sore throat; irregular heartbeat; joint pain; memory problems; muscle tenderness, pain, or weakness with or without fever and fatigue; red, swollen, blistered, or peeling skin; severe stomach or back pain with or without nausea or vomiting; swelling of the hands, ankles, or feet; symptoms of liver problems eg, dark urine, loss of appetite, pale stools, severe stomach pain, yellowing of the skin or eyes; trouble sleeping; unusual bruising or bleeding; unusual tiredness or weakness; vomiting. Many herbs can interact with prescription medicines. Always check with your doctor or pharmacist before you take herbal products. Simvastatin Oral Suspension and call their healthcare professional. Simvastatin has important interactions with juice and other drugs, including some that are commonly used for the treatment of cardiovascular disease. There may be new information. Good luck with your recovery and be very careful with statin drugs. They pretty much all have the same nasty side effects. including the natural statin, red rice yeast. Women who are pregnant or may become pregnant. Concomitant administration of simvastatin with verapamil, diltiazem, or dronedarone: The dose of simvastatin should not exceed 10 mg per day. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. DilTIAZem: Simvastatin may increase the serum concentration of DilTIAZem. DilTIAZem may increase the serum concentration of Simvastatin. Management: Avoid concurrent use of diltiazem with simvastatin when possible. Park, D. K. Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells. Life Sci. Bays HE, Dujovne CA. Drug interactions of lipid-altering drugs. Risk categories are based on the Framingham Heart Study to estimate 10-year risk for coronary heart disease heart attack and coronary death. It is based on adults ages 20 and older who do not have heart disease or diabetes. Statins may also help to stabilize plaques in the arteries. That makes heart attacks less likely. If you become or think you may be pregnant, tell your doctor right away. Pan, T. M. Synchronous analysis method for detection of citrinin and the lactone and acid forms of monacolin K in red mold rice. seafood mentax

General information about simvastatin

Make sure your concerns are valid before you reject a statin -- their benefits to your are noteworthy. Can Exercise and Diet Lower Your Cholesterol Enough? Jiang HP. Comparison of the therapeutic effects and compliance of Xuezhikang and Fenofibrate in patients with hyperlipidemia. Muscle problems myopathy may occur with simvastatin. The risk of muscle problems may be greater in people who take higher doses of simvastatin, in people older than 64 years old, in females, or in people who have kidney problems or low thyroid function. It may also be greater in those who take it with certain other medicines eg, niacin especially in Chinese patients. Tell your doctor right away if you notice any unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or general body discomfort. Tell your doctor if you have muscle problems that persist even after your doctor has told you to stop taking simvastatin. Goma, G. Pigments of Monascus. Take this by with or without food as directed by your doctor, usually once daily in the evening. There are no direct drug interactions between simvastatin and alcohol. A moderate intake of alcohol is unlikely to cause problems with simvastatin for most people. However, people with long-term alcohol problems or people who regularly consume large quantities of alcohol may not be able to safely take this medication. The main side effects are flushing, itching, tingling, and headache. Aspirin can reduce many of these symptoms. Speak with your doctor first, though, before taking aspirin. Research studies suggest that even though niacin may improve your cholesterol numbers, it does not appear to lower your risk of heart disease, especially if you are already taking a statin. Deng YM, Meng MK Liao YZ. Clinical observation of Xuezhikang on treatment of elderly patients with primary mixed hyperlipidemia. Your body needs cholesterol for cell structure, nerve function, digestion and many other vital processes. Your body makes its own cholesterol in the liver. Fatty foods and meats also contain cholesterol, which ends up floating around in the bloodstream. Overtime, this extra cholesterol adheres to the walls of arteries, forming a rigid plaque that can restrict blood flow. Sometimes, this restriction is so drastic it can cause heart attacks and strokes, among other serious cardiovascular problems. Li, Y. L. Effect of xuezhikang, a cholestin extract, on reflecting postprandial triglyceridemia after a high-fat meal in patients with coronary heart disease. Safety of red yeast rice. Fisher Center for Alzheimer's Research Foundation: “Cholesterol-Lowering Statins May Ward off Dementia. Lu, Z. Clinical trial of extract of Monascus purpureus red yeast in the treatment of hyperlipidemia. Imatinib: May decrease the metabolism of Simvastatin. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk.

How is High Blood Cholesterol Treated?

Ong, H. T. and Cheah, J. S. Statin alternatives or just placebo: an objective review of omega-3, red yeast rice and garlic in cardiovascular therapeutics. Chin Med. Biochemist Jesse Huff and his colleagues at Merck began researching the biosynthesis of cholesterol in the early 1950s. This may not be a complete list of all interactions that may occur. Ask your health care provider if simvastatin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. The control group had no such change. Shen ZW, Yu PL Sun MZ Chi JM Zhou YF Zhu XS Yang CY He CF. Prospective study of Xuezhikang for treatment of primary hyperlipidemia. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Li LH, Deng GL Chen YZ. CIinical comparative study of simvastatin and Xuezhikang and pravastatin in common doses on primary hyperlipidemia. Niacin is a B-complex vitamin. It's found in food, but is also available at high doses by prescription. It lowers LDL cholesterol and raises HDL cholesterol. These drugs also lower elevated triglycerides. The main side effects are flushing, itching, tingling, and headache, yet aspirin can reduce many of these symptoms. However, speak with your doctor first. Niacin or nicotinic acid, includes the brand names Niacor, Niaspan, or Slo-niacin. Over-the-counter preparations include extended-release, timed-release, and controlled-release. Niacin found in dietary supplements should not be used to lower cholesterol. Your doctor or lipid specialist will let you know if niacin is appropriate for you. Recent research suggests that niacin may improve cholesterol numbers, but may not be associated with prevention of heart attacks. Evaluate for new-onset diabetes mellitus during therapy; if diabetes develops, continue statin therapy and encourage adherence to a heart-healthy diet, physical activity, a healthy body weight, and tobacco cessation. colospa

Reviews for simvastatin

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of simvastatin in children 10 to 17 years of age. However, safety and efficacy of simvastatin in children younger than 10 years of age have not been established. Chen GY. Observations on the therapeutic effects of Zhibituo for treatment of hyperlipidemia in the elderly. Dr. Alan Garber, a professor at Baylor College of Medicine, said that statin users with blood sugar levels beginning to creep up can likely head off type 2 diabetes through diet and exercise. Garber is the editor of the journal Diabetes, Obesity and Metabolism. What Are Possible Side Effects of Zocor? If nausea, vomiting, or diarrhea occurs, ask your doctor for ways to lessen these effects. Contact your doctor right away if you experience severe or persistent diarrhea, nausea, or vomiting. US Dept Health, Human Services, FDA. price for clopidogrel pills

Simvastatin dosing information

When you take a statin, you do more than improve your cholesterol levels. VYTORIN and placebo, respectively. Lipid panel total cholesterol, HDL, LDL, triglycerides: Baseline lipid panel; fasting lipid profile within 4 to 12 weeks after initiation or dose adjustment and every 3 to 12 months as clinically indicated thereafter. TG between the two treatment groups were not significantly different. Wang WH. Comparison of Xuezhikang and atorvastatin efficacy of treatment of hypercholesterolemia. Diabetes mellitus: Increases in HbA 1c and fasting blood glucose have been reported with HMG-CoA reductase inhibitors; however, the benefits of statin therapy far outweigh the risk of dysglycemia. Based on your overall risk, your doctor may recommend you take statins to help lower your by a certain percentage. More than 29 million people in the United States have diabetes, according to the American Diabetes Association ADA. Type 2 diabetes occurs when the body becomes resistant to insulin, a hormone needed to process the sugars found in foods. To compensate, the body produces more insulin. Excess weight and a sedentary lifestyle are two important risk factors for type 2 diabetes, according to the ADA. Maintain a desirable weight. The results were published in the journal Care. Wang, J. The clinical examinations of Xue-Zhi-Kang in the treatment for hypercholesterolemia. Xu JM, Chen SX Hu WY Cai NS Xu Q Wu ZG Sun KX. Zhibituo vs. placebo treatment of hyperlipidemia a double blind randomized and multicenter study. price hydrochlorothiazide forum

Safety of red yeast rice

Many studies show that almonds have real health benefits too. Jie Jack Li 2009. Sobh, M. Efficacy and safety of Monascus purpureus Went rice in subjects with secondary hyperlipidemia. Fusidic Acid Systemic: May increase the serum concentration of CYP3A4 Substrates. Using simvastatin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. chantix

IV, and V dyslipidemias

Deep tissue massage is best for giving attention to certain painful, stiff "trouble spots" in your body. Shake bottle well for at least 20 seconds before using. Statins are more effective than other lipid-regulating drugs at lowering LDL- concentration, but they are less effective than the fibrates in reducing triglyceride concentration. However, statins reduce cardiovascular disease events and total mortality irrespective of the initial cholesterol concentration. This is a major piece of evidence that statins work in another way than the lowering of cholesterol called pleiotropic effects. Gemfibrozil Lopid can affect the muscles. Red yeast can also affect the muscles. Taking gemfibrozil along with red yeast might increase the risk of muscle problems. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. VYTORIN, promptly interrupt therapy. Yan HD, Guo JH Jia ST. Observations of the short-term effects of Probucol in treatment of hyperlipidemia. Simvastatin should be taken as single dose in the evening. Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with or not feel sick.

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Does simvastatin interact with other medications

Dosage may be adjusted in this condition

Use with caution. May cause side effects to become worse. Bargossi AM, Battino M, Gaddi A, et al. Exogenous CoQ10 preserves plasma ubiquinone levels in patients treated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. When used together with higher doses of simvastatin, these medicines may increase your risk of muscle injury and could result in kidney problems. Liu, Z. and Zhang, Y. Clinical observation of treatment of hyperlipidemia with Xuezhikang.

Simvastatin brand names

Endo, A. Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J Antibiot. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use. This medication may rarely cause problems. Use simvastatin as directed by your doctor. Check the label on the medicine for exact dosing instructions. Patients who are currently tolerating the 80 mg dose who need to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin should be switched to an alternative statin with less potential for the drug-drug interaction.

Highlights for simvastatin

At a minimum I would recommend that you stop statin therapy immediately and see your doc specifically about statin reaction problems. My doc would not believe that statins cause these issues he has been brainwashed by big Pharma. You should also start taking large CO-Q-10 and L-Carnitine supplements daily as well to help with muscle repair and healing. Almost all my investigations indicate that IF you MUST take a statin drug, it should be NO MORE than 10 mg. per day unless you are taking it after heart surgery etc. Preferably not at all. Dabrafenib: May decrease the serum concentration of CYP3A4 Substrates. Management: Seek alternatives to the CYP3A4 substrate when possible. If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely particularly therapeutic effects.

Fredrickson type III hyperlipidemia

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients. Diarrhea; headache; symptoms of upper respiratory tract infection eg, mild cough or sore throat, runny or stuffy nose, sneezing. HMG-CoA Reductase Inhibitors. Specifically, the risk for muscle toxicities, including rhabdomyolysis may be significantly increased. Management: Avoid concurrent use whenever possible. Use is listed as contraindicated in product characteristic summaries in several countries, although UK labeling suggests that use could be considered under exceptional circumstances and with close supervision.

This drug may rarely cause muscle problems which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy. The primary uses of simvastatin are to treat and to prevent atherosclerosis-related complications such as stroke and heart attacks in those who are at high risk. It is recommended to be used as an addition to a low cholesterol diet. Annu. Rev. Pharmacol. Toxicol. Sept. 10, 2002; vol 106: pp 1327-1332.

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